Publications

fold faq

Year 2014

Akbalik, G., and Schuman, E.M. (2014). mRNA, Live and Unmasked. Science, 24 (6169): 375-376. pdf

Bagert, J.D., Xie, Y.J., Sweredoski, M.J., Qi, Y., Hess, S., Schuman, E.M., and Tirrell, D.A. (2014). Quantitative, time-resolved proteomic analysis by combining bioorthogonal noncanonical amino acid tagging and pulsed stable isotope labeling by amino acids in cell culture. Mol. Cell. Proteomics, 13(5):1352-8 pdf

Hanus, C., Kochen, L., tom Dieck, S., Racine, V., Sibarita, J.B., Schuman, E.M., and Ehlers, M.D. (2014). Synaptic Control of Secretory Trafficking in Dendrites. Cell Rep 7: 1-8 pdf

Perkovic, M., Kunz, M., Endesfelder, U., Bunse, S., Wigge, C., Yu, Z., Hodirnau, V.V., Scheffer, M.P., Seybert, A., Malkusch, S., Schuman, E.M., Heilemann, M., and Frangakis, A.S. (2014) Correlative Light- and Electron Microscopy with chemical tags. Journal of Structural Biology 186(2):205-13 pdf

Tom Dieck, S., Hanus, C., and Schuman, E.M. (2014) SnapShot: Local Protein Translation in Dendrites. Neuron, 81(4): 958-958. pdf

fold faq

Year 2013

Bunse, S., Garg, S., Junek, S., Vogel. D., Ansari, N., Stelzer, E.H.K., and Schuman, E.M. (2013). Role of N-cadherin cis and trans interfaces in the dynamics of adherens junctions in living cells. PLoS ONE, 8(12): e81517 pdf

Epstein, I., Tushev, G., Will, T.J., Vlatkovic, I., Cajigas, I.J., Schuman, E.M. (2013). Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil. Phil. Trans. R. Soc. B 369: 20130137. pdf

Hanus, C.T. and Schuman, E.M. (2013). Proteostasis in dendrites. Nature Reviews Neuroscience 14, 638–648 (2013). pdf

Hinz, F.I., Tushev, G., Aizenberg, M., and Schuman, E.M. (2013). Protein synthesis-dependent associative long-term memory in larval zebrafish. Journal of Neuroscience, 33 (39), 15382-15387.  pdf

Hinz, F.I., Dieterich, D.C., and Schuman, E.M. (2013). Teaching old NCATS new tricks: Using non-canonical amino acid tagging to study neuronal plasticity. Current Opinion in Chemical Biology 17(5), 738–746. pdf

Holt, C.E. and Schuman, E.M. (2013). The central dogma decentralized: new perspectives on RNA function and local translation in neurons. Neuron 80 (3), 648-657 (2013) pdf

Ngo, J.T., Schuman, E.M. and Tirrell, D.A. (2013). A mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells. Proc. Natl. Acad. Sci., 110(13), 4992-4997. pdf

Taylor, A., Wu, J., Tai, H.C. and Schuman, E.M. (2013). Axonal translation of β-catenin regulates synaptic vesicle dynamics. Journal of Neuroscience 33(13): 5584–5589. pdf

Will, T.J., Tushev, G., Kochen, L., Nassim-Assir, B., Cajigas, I.J., tom Dieck, S., and Schuman, E.M. (2013). Deep-Sequencing and High-Resolution Imaging Reveal Compartment-Specific Localization of Bdnf mRNA in Hippocampal Neurons. Science Signaling, 6 (306), rs16 pdf

fold faq

Year 2012

tom Dieck, S., Müller, A., Nehring, A., Hinz, F.I., Bartnik, I., Schuman, E.M., Dieterich, D.C. (2012) Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging. Current Protocols in Cell Biology, Chapter 7: Unit 7.11. pdf

Ngo, J.T., Babin, B.M., Champion, J.A., Schuman, E.M. and Tirrell, D.A. (2012). State-selective metabolic labeling of cellular proteins. ACS Chemical Biology, 7(8), 1326-1330. pdf

Hodas, J.J.L., Nehring, A., Höche, N., Sweredoski, M.J., Pielot, R., Hess, S., Tirrell, D.A., Dieterich, D.C., Schuman, E.M. (2012). Dopaminergic modulation of the hippocampal neuropil proteome identified by bio-orthogonal non-canonical amino-acid tagging (BONCAT). Proteomics, 12(15-16): 2464-76. pdf

Cajigas, I.J., Tushev, G., Will, T.J., tom Dieck, S., Fuerst, N., and Schuman, E.M. (2012). The local transcriptome in the synaptic neuropil revealed by deep sequencing and high resolution imaging. Neuron, 74: 453-466 pdf

Ito, H. and Schuman, E.M. (2012).  Functional division of hippocampal area CA1 via modulatory gating of entorhinal cortical inputs. Hippocampus, 22:2, 372-387  pdf

Hinz, F.I., Dieterich, D.C., Tirrell, D.A., and Schuman, E.M. (2012). Non-canonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish. ACS Chemical Neuroscience, 3 (1), 40-49 pdf

fold faq

Year 2011

Kim, S.A., Tai, Chin-Yin, Mok, Lee-Peng, Mosser, E.A., Schuman, E.M. (2011). Calcium-dependent dynamics of cadherin interactions at cell-cell junctions. Proc. Natl. Acad. Sci., 108 (24), 9857-9862 pdf

Aizenberg, M. and Schuman, E.M. (2011). Cerebellar-dependent learning in larval zebrafish. Journal of Neuroscience, 31(24), 8708-8712.  pdf

fold faq

Year 2010

Szychowski, J., Mahdavi, A., Hodas, J.J.L., Bagert, J.D., Ngo, J.T., Landgraf, P., Dieterich, D.C., Schuman, E.M., Tirrell, D.A. (2010). Cleavable Biotin Probes for Labeling of Biomolecules via Azide-Alkyne Cycloaddition. Journal of the American Chemical Society: 132 (51), 18351–18360.  pdf

Schuman, E., Zhuang X. (2010). New Technologies. Editorial overview. Current Opinion in Neurobiology, 20:608-609.  pdf

Cajigas, I.J., Will, T., and Schuman, E.M. (2010). Protein homeostasis and synaptic plasticity. The EMBO Journal, 29, 2746-2752.  pdf

Dieterich, D.C., Hodas, J.J.L., Gouzer, G., Shadrin, I.Y., Ngo, J.T., Triller, A., Tirrell, D.A., and Schuman, E.M. (2010). In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nature Neuroscience, 13, 897-905.  pdf

Tai, Hwan-Ching, Besche H., Goldberg A.L. and Schuman E.M. (2010).  Characterization of the brain 26S proteasome and its interacting proteins. Frontiers in Molecular Neuroscience, 3:12.  pdf

Taylor, A.M., Dieterich, D.C., Cho, J.Ito, H., Kim, S.A., and Schuman, E.M. (2010). Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron, 66, 57-68.   pdf

Rutishauser, U., Ross, I.B., Mamelak,A.N. and Schuman, E.M. (2010). Human memory strength is predicted theta-frequency phase-locking of single neurons.  Nature, 464: 903-907.  pdf

Tai, Hwan-Ching and Schuman, E.M. (2010). Angelman Syndrome: Finding the Lost Arc.  Cell, 140, 608-610.  pdf

fold faq

Year 2009

Ito, H. and Schuman, E.M. (2009). Distance-dependent homeostatic synaptic scaling mediated by A-type potassium channels. Frontiers in Cellular Neuroscience, 3:15.  pdf

Ngo JT, Champion JA, Mahdavi A, Tanrikulu IC, Beatty KE, Connor RE, Yoo TH, Dieterich DC, Schuman EM, Tirrell DA.  (2009). Cell-selective metabolic labeling of proteins. Nature Chemical Biology, 2009, 5,715-7. pdf

Sutton, M.A. and Schuman, E.M. (2009).  Partitioning the synaptic landscape: distinct microdomains for spontaneous and spike-triggered neurotransmission.  Science Signaling, 7, 19.  pdf

fold faq

Year 2008

Tai, H.C. and Schuman, E.M. (2008).  Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction.  Nature Reviews Neuroscience, 11, 826-38.  pdf

Tai, C.Y., Kim, S.A., and Schuman, E.M. (2008).  Cadherins and Synaptic Plasticity. Current Opinion in Cell Biology 5, 567-575.  pdf

Mysore SP, Tai CY, Schuman EM.  (2008) N-cadherin, spine dynamics, and synaptic function. Frontiers in Neuroscience, Dec;2(2):168-75.  pdf

Ito HT, Schuman EM.  (2008) Frequency-dependent signal transmission and modulation by neuromodulators. Frontiers in Neuroscience, Dec;2(2):138-44.  pdf

fold faq

Year 2007

Ito, H. and Schuman, E.M. (2007).  Frequency-dependent gating of synaptic transmission and plasticity by dopamine.  Frontiers in Neural Circuits, 1, 1-13.  pdf

Mysore, S. P., Tai, C-Y, and Schuman, E. M. (2007).  Effects of N-cadherin disruption on spine morphological Dynamics.  Frontiers in Cellular Neurosci., 1, 1-14.  pdf

Rutishauser, U., Schuman, E.M. and Mamalak, A.N. (2007).  Activity of human hippocampal and amygdala neurons during retrieval of episodic memories.  Proc. Natl. Acad. Sci., 105, 1:329-334. pdf

Antion, M.D., Merhav, M., Hoeffer, C.A., Reis, G., Kozma, S.C., Thomas, G., Schuman, E.M., Rosenblum, K., and Klann, E. (2008). Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learn. Mem. 15, 29-38. pdf

Sutton, M. A., Taylor, A.M., Ito, H.T., Pham, A. and Schuman, E.M. (2007).  Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis.  Neuron, 55, 648-661.  pdf

Tai, C.Y., Mysore, S.P., Chiu, C. and Schuman, E.M. (2007).  Activity-regulated N-cadherin endocytosis. Neuron, 54, 771-85.  pdf

Dieterich, D.C., Lee, J.J., Link, A.J., Graumann, J., Tirrell, D.A., and Schuman, E.M. (2007).  Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging. Nature Protocols, 2, 532-540.  pdf

fold faq

Year 2006

Beatty, K., Liu, J. Dieterich, D.C., Schuman, E.M. and Tirrell, D.T.  (2006).  Fluorescence Visualization of Newly Synthesized Proteins in  Mammalian Cells.  Angewandte Chemie, 45, 7364-7367.  pdf

Sutton, M.A. and Schuman, E.M. (2006).  Dendritic protein synthesis, synaptic plasticity and memory. Cell, 127, 49-57.  pdf

Schuman, E.M., Dynes, J.L., and Steward, O. (2006). Synaptic regulation of translation of dendritic mRNAs. J. Neurosci., 26, 7143-7146. pdf

Bingol, B. and Schuman, E.M. (2006).  Activity-dependent dynamics and sequestration of the proteasome in dendritic spines. Nature, 441, 1144-1148.   pdf

Dieterich, D.N., Link, A.J., Graumann, J., Tirrell, D.T. and Schuman, E.M. (2006). Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal non-canonical amino acid tagging (BONCAT). Proc. Natl. Acad. Sci., 103, 9482-9487.  pdf

Sutton, M.A., Ito, H., Cressy, P., Kempf, C., Woo, J. and Schuman, E.M. (2006).  Miniature synaptic transmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis. Cell, 125, 785-799.  pdf

Rutishauser, U., Schuman, E.M. and Mamelak, A.N. (2006).  Online detection and sorting of extracellularly recorded action potentials in human medial temporal lobe recordings, in vivo. J. Neurosci. Meth., 49, 805-813.  pdf

Rutishauser, U., Mamelak, A.N., and Schuman, E.M. (2006).  Learning, novelty and familiarity detection in single neurons of the human hippocampus-amygdala complex. Neuron, 49, 805-813.  pdf

Tai, H.C. and Schuman, E.M. (2006).  MicroRNAs reach out into dendrites. Current Biology, 16, R121-123.  pdf

fold faq

Year 2005

Bingol, B. and Schuman, E.M.  (2005).  Synaptic protein degradation by the ubiquitin proteasome system. Curr. Op. Neurobiol., 15, 536-541.  pdf

Goard, M., Aakalu, G., Fedoryak, O.D., Quinonez, C., St. Julien, J., Poteet, S.J., Schuman,E.M. and Dore, T.M.  (2005).  Light-mediated inhibition of protein synthesis.  Chemistry and Biology, 12, 685-93.  pdf

Sutton, M.A. and Schuman, E.M. (2005).  Local translational control in dendrites and its role in long-term synaptic plasticity.  J Neurobiol., 64, 116-31.  pdf

Smith, W.B., Starck, S.R., Roberts, R.W. and Schuman, E.M. (2005).  Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron, 45, 765-779.  pdf

Bhattcharya, J., Edwards, J., Mamelak, A.N., and Schuman, E.M. (2005). Long-range temporal correlations in the spontaneous spiking of neurons in the hippocampal-amygdala complex of humans.  Neuroscience, 131, 547-55. pdf

fold faq

Year 2004

Schuman, E.M. and Chan, D. (2004).  Fueling Synapses.  Cell, 119, 738-740.  pdf

Remondes, M. and Schuman, E.M.  (2004).  Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory. Nature, 431: 699-703.  pdf

Sutton, M.A, Aakalu, G.N., Wall, N. and Schuman, E.M. (2004).  Miniature synaptic events regulate local protein synthesis in the dendrites of hippocampal neurons.  Science, 304, 1979-1983.  pdf

Bingol, B. and Schuman, E.M. (2004).  A proteasome-sensitive connection between PSD-95 and GluR1 endocytosis.  J. Neuropharmacology, 47: 755-763.  pdf

fold faq

Year 2003

Patrick, G.N., Bingol, B., Weld, H.A., and Schuman, E.M. (2003). Ubiquitin-mediated proteasome activity is required for agonist-induced endocytosis of GluRs. Current Biology, published online 10/20/03, 13, 2073-2081.  pdf

Steward, O. and Schuman, E.M. (2003).  Compartmentalized synthesis and degradation of proteins in neurons. Neuron, 40: 347-359.  pdf

Remondes, M. and Schuman, E.M. (2003).  Molecular mechanisms contributing to long-lasting synaptic plasticity at the temporoammonic-CA1 synapse. Learning and Memory, 10: 247-252.  pdf

Murase, S. and Schuman, E.M. (2003).  Cadherins and synaptic plasticity: activity-dependent cyclin-dependent kinase 5 regulation of synaptic beta-catenin-cadherin interactions.  Philos. Trans. Royal Society, 358: 749-756.  pdf

fold faq

Year 2002

Jiang, C. and Schuman, E.M. (2002).  Regulation and function of local protein synthesis in neuronal dendrites.  TIBS, 27: 506-513.  pdf

Murase, S., Mosser, E., Schuman, E.M. (2002).  Depolarization drives β-catenin into neuronal spines promoting changes in synaptic structure and function. Neuron, 35, 91-105.  pdf

Remondes, A.M. and Schuman, E.M. (2002).  Modulation of plasticity and information transfer in CA1 pyramidal cells by a direct entorhinal input. Nature, 416: 736-740.  pdf

Tang, S.J., and Schuman, E.M. (2002). Protein synthesis in the dendrite. Philos. T. Roy. Soc. B., 357, 521-529. pdf

Tang, S., Reis, G., Kang, H.  Gingras, A.C., Sonenberg, N. and Schuman, E.M. (2002).  A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity  in the hippocampus. PNAS, 99, 467 72.  pdf

fold faq

Year 2001

Tang, S., Meulmans, D., Vasquez, L., Colaco, N., Schuman, E.M. (2001).  A Role for Staufen in the Delivery of RNA to Neuronal Dendrites. Neuron, 8, 463-475.

Smith, W.B., Aakalu, G.N. and Schuman, E.M. (2001).  Local protein synthesis in neurons.  Current Biology, 11: R901-903.

Aakalu, G., Smith, W.B., Nguyen, N., Jiang, C. and Schuman, E.M. (2001).  Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons. Neuron, 30: 489-502.

Steward, O. and Schuman, E.M.  Protein synthesis at synaptic sites on dendrites. (2001).  Ann. Rev. Neurosci., 24, 299-325.

D’Apuzzo, M., Mandolesi, G. and Schuman, E.M. (2001).  Abundant GFP expression and synaptic plasticity followingLTP in hippocampal acute slices by in vivo Sindbis Virus injection. of sindbis virus.  J. Neurophysiol., 86: 1037-1042.

fold faq

Year 2000

Kang H, Schuman E.M. (2000).  Intracellular Ca(2+) signaling is required for neurotrophin‑induced   potentiation in the adult rat hippocampus. Neurosci Lett. 283(3):141‑4.

fold faq

Year 1999

Dvorak-Carbone, H. and Schuman, E.M.  (1999).  Patterned activity in stratum lacunosum moleculare inhibits CA1  pyramidal neuron firing.  J. Neurophysiol. 82: 3213‑3222

Murase, S. and Schuman, E.M. (1999).  The role of cell adhesion molecules in synaptic plasticity and memory.  Curr. Op. Cell Biol., 11: 549-553.

Schuman, E.M. (1999).  mRNA Trafficking and Protein Synthesis at the Synapse. Neuron, 23: 645-648.

Ma, L., Reis, G., Parada, L.F., and Schuman, E.M. (1999).  Neuronal NT-3 is not required for synaptic transmission or long-term potentiation in area CA1 of the adult rat hippocampus.  Learning & Memory, 6: 267-275.

Schuman, E.M. (1999).  Neurotrophin regulation of synaptic transmission.  Curr. Op. Neurobiol., 9: 105-109.

Dvorak-Carbone, H. and Schuman, E.M.  (1999).  Long-term depression of temporoammonic-CA1 hippocampal synaptic transmission.  J. Neurophysiol., 81: 1036-1044.

Ouyang, Y., Rosenstein, A., Kreiman, G., Schuman, E. M., and Kennedy, M. B. (1999).  Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons.  J. Neurosci. 19, 7823-7833.Schuman, E., Smith, B., Tang, S., Aakalu, G., Meulmans, D., Vazquez, L., Tsung, M., and Reis, G. (1999). Protein synthesis in hippocampal neurons: Implications for synapse specificity. Faseb J., 13, A703-A703

fold faq

Year 1998

Li, Y.X., Zhang, Y., Lester, H.A., Schuman, E.M., Davidson, N. (1998).  Enhancement of excitatory neurotransmitter release induced by brain-derived neurotropic factor in cultured hippocampal neurons.  J. Neurosci., 18: 10231-10240.

Li, Y.X., Xu, Y.,  Ju, D., Lester, H.A., Davidson, N., and Schuman, E.M.  (1998).  Expression of a dominant negative Trk B receptor, T1, reveals a requirement for presynaptic signaling in BDNF-induced synaptic potentiation in cultured hippocampal neurons.  PNAS, 95: 10884‑10889

Tang, L.X., Hung, C.P. and Schuman, E.M. (1998).  A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Neuron, 20: 1165-1175.

Korte, M., Kang, H., Bonhoeffer, T. and Schuman, E.M. (1998).  A role for BDNF in the late-phase of hippocampal long-term potentiation. J. Neuropharmacol., 37, 553-560.

Ehrengruber, M. U., Lanzrein, M., Xu, Y., Jasek, M. C., Kantor, D. B., Schuman, E. M., Lester, H. A. and Davidson, N. (1998).  Recombinant adenovirus‑mediated expression in the nervous system of genes coding for ion channels and other molecules involved in synaptic function.  Meth. in Enzymol. 293, 483‑503.

fold faq

Year 1997

Kang, H., Shelton, D., Welcher, A. and Schuman, E.M. (1997).  Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation. Neuron19, 653-664.

Ouyang, Y., Kantor, D.B., Harris, K.M., Schuman, E.M. and Kennedy, M.B. (1997).   Visualization of the distribution of autophosphorylated calcium/calmodulin‑dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus.  Journal of Neuroscience,17: 5416‑5427.

Sullivan, B.M., Wong, S. and Schuman, E.M. (1997).  Modification of hippocampal synaptic proteins by nitric oxide-stimulated ADP ribosylation. Learning & Memory, 3, 414-424.

Schuman, E.M. (1997).  Synapse specificity and long-term information storage. Neuron, 18, 339-342.

Schuman, E.M. (1997).  Growth factors sculpt the synapse. Science, 275, 1277-1278.

fold faq

Year 1996

Kantor, D., Lanzrein, M. Stary, J., Sandoval, G.R., Smith, B., Sullivan, B.M., Davidson, N., and Schuman, E.M. (1996).  Adenovirus-mediated inhibition and rescue reveals a role for endothelial nitric oxide synthase in hippocampal long-term potentiation.A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science, 274, 1744-1748.

Kang, H. and Schuman, E.M. (1996).  A requirement for local protein synthesis in neurotrophin-induced synaptic plasticity. Science, 273, 1402-1406.

Kang, H., Jia, L., Suh, K.Y., Tank, L. and Schuman, E.M. (1996).  Determinants of BDNF- induced potentiation in hippocampal slice: effectssynaptic plasticity: role of the Trk B antibodiesreceptor and perfusion rate.the kinetics of neurotrophin delivery.  Learning & Memory, 3, 188-197.

fold faq

Year 1995

Kang, H. and Schuman, E.M. (1995).  Neurotrophin-induced modulation of synaptic activity in the adult hippocampus. J. Physiol. (Paris), 89, 11-23.

Kang, H. and Schuman, E.M. (1995).  Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science, 267, 1658-1662.

Interactive

ShareThis
ShareThis